Another explanation could be that in Pac-Man, the only time the Ghosts flee from Pac-Man is when there Blue. Hence Lil Wayne is saying he is a constant aggressor towards anyone who opposes him.
Hes more than likely referring to having so much drugs in his trunk that his car is heavy in the rear and lifting the front end up. Hence, popping a wheelie.
A "package" is urban slang for a delivery of drugs. His "whip game proper" means that he knows to use inconspicuous cars at legal speeds to not alert the attention of authorities when delivering said drugs via automobile.
In this line, Wayne is just saying that he has a lot of problems & he addresses them, like P.O. boxes instead of ignoring them; because P.O. boxes have adresses. Its really simple.