This lyric refers to the rapper commuting to conduct activities in his territory of choice, in this case being Saint Clair Avenue in the city of Cleveland.
something significant is going to happen in Cleveland, Ohio where Bone Thugz are from
I have to make one thousand dollars, at minimum, every day.
Saying they've been or will shoot whoever they consider a fool. Dumpin slugs: shooting rounds of ammunition.
I'm constantly making money--ends comes from the term to make ends meet.